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Komen Funded Research Helps Scientist Develop Vaccine Against An Early Form of Breast Cancer

November 16, 2011

 

 

Ductal carcinoma in situ (DCIS) is the most common type of non-invasive breast cancer in the United States, with more than 60,000 women diagnosed each year. Although women with DCIS have a very high cure rate, at least 30% require more aggressive treatments.

An innovative breast cancer vaccine, developed by Dr. Brian Czerniecki at the University of Pennsylvania, could offer women with DCIS an alternative to surgery or chemotherapies. The concept for the vaccine began in 1996 with a Komen-funded research grant. To make the vaccine, white blood cells are taken from a patient and modified to recognize breast cancer cells. When injected back into the patient, these cells help the immune system identify and attack the tumor.

Preliminary data generated from the Komen grant led to funding from the National Cancer Institute to conduct a clinical trial of the vaccine. Several women have already been treated and results appear promising. The vaccine could potentially diminish the risk of recurrence, protect against invasive breast cancer, and minimize morbidity associated with current treatments. Read more

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